ArtesunĀ®

Fosun Pharma

Product category
  • Severe malaria treatment (artesunate for injection)

Therapeutic indication
  • Treatment of severe malaria caused by the parasite P. falciparum, to be followed by a full course of ACT

Dosing
  • At least 3 injections within 1 day during critical phase

Efficacy
  • 92% survival vs 88% survival with quinine in African children

  • Coma duration, convulsions, and hypoglycaemia significantly lower with artesunate compared to quinine

Key features
  • WHO-prequalified injectable artesunate

  • Cost per disability-adjusted life year (DALY) averted: US$ 3.8

Challenges
  • Potential for delayed haemolytic anaemia

  • Continued use of quinine or artemether for injection

Status
  • WHO prequalification in 2010

  • Approved in 33 countries; 168 million ArtesunĀ® vials shipped since prequalification

Next milestone
  • Simplified injectable artesunate two-vial to be developed for WHO prequalification review

  • Additional country registrations

MMV Project Director
  • Hans Rietveld