Tafenoquine
Single-dose Kozenis (tafenoquine) approved for children with Plasmodium vivax malaria by Australian Therapeutic Goods Administration
Medicines for Malaria Venture (MMV) today announces that the Australian Therapeutic Goods Administration (TGA) has approved the use of single-dose Kozenis (tafenoquine) in children aged 2 years and above in combination with chloroquine for the radical cure (prevention of relapse) of Plasmodium vivax (P. vivax) malaria.
The approval includes a novel, 50 mg dispersible tablet that can be dispersed in water and which was developed by GSK in partnership with MMV to facilitate use in children, who are disproportionately affected by the disease.
First real-world use of new protocol for P. vivax case management in Brazil – a Health Ministry and MMV collaboration
Since September this year, patients diagnosed with Plasmodium vivax (P. vivax) malaria in the municipalities of Manaus and Porto Velho in Brazil have been receiving a new treatment protocol as part of an innovative programme led by the Ministry of Health (MoH). The new protocol includes testing for G6PD deficiency before P. vivax radical cure with either single-dose tafenoquine, developed by MMV and GSK, or 7-day primaquine, the current standard of care.
The burden of relapsing P. vivax malaria on families
Nossa Senhora de Fatima is a remote village located in the middle of the Brazilian Amazon. In addition to being one of the most beautiful places in Brazil, the Amazonian region also accounts for 99.5% of all national malaria cases.
New report demonstrates how R&D partnerships serving neglected communities have developed dozens of life-saving innovations since 2010
The public-private initiatives that contributed to COVID-19 vaccine and drug development have showcased a model for accelerating biomedical innovation. This is another powerful example of how public-private partnerships have established themselves as powerhouses for fighting global health threats.
GSK, MMV filing for Kozenis (tafenoquine) in paediatric populations with Plasmodium vivax malaria accepted by Australian Therapeutic Goods Administration
GSK and Medicines for Malaria Venture (MMV) announced today that the Australian Therapeutic Goods Administration (TGA) accepted the submission of a Category 1 application to extend the indication of single-dose Kozenis (tafenoquine) to paediatric populations for the radical cure (prevention of relapse) of Plasmodium vivax (P. vivax) malaria.
The application includes data for a new, 50 mg tablet that can be dispersed in water and which was developed to facilitate use in children, who are disproportionately affected by the disease.
Brazil becomes first malaria-endemic country to approve single-dose tafenoquine (Kozenis) for radical cure of P. vivax malaria
GSK Brazil and Medicines for Malaria Venture (MMV) today announced that the Brazilian Health Regulatory Agency (ANVISA) has granted Marketing Authorization Approval, under Priority Review, for single-dose tafenoquine (brand name Kozenis) for the radical cure (prevention of relapse) of Plasmodium vivax (P. vivax) malaria in patients aged 16 years and older who are receiving chloroquine for acute P. vivax (blood-stage) infection.
MMV and PATH strengthen ties with APLMA in the fight against relapsing malaria
Last week at the Asia Pacific Malaria Elimination Network (APMEN) meeting in Nepal, MMV, PATH and the Asia Pacific Leaders Malaria Alliance (APLMA) announced their strengthened collaboration to introduce new tools to support malaria elimination in the Greater Mekong and Asia Pacific.
Stopping the malaria relapse
Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax Malaria
The New England Journal of Medicine
DOI: 10.1056/NEJMoa1802537
Abstract
BACKGROUND
Tafenoquine, a single-dose therapy for Plasmodium vivax malaria, has been associated with relapse prevention through the clearance of P. vivax parasitemia and hypnozoites, termed “radical cure.”
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