Tafenoquine
MMV and PATH strengthen ties with APLMA in the fight against relapsing malaria
Last week at the Asia Pacific Malaria Elimination Network (APMEN) meeting in Nepal, MMV, PATH and the Asia Pacific Leaders Malaria Alliance (APLMA) announced their strengthened collaboration to introduce new tools to support malaria elimination in the Greater Mekong and Asia Pacific.
Stopping the malaria relapse
Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax Malaria
The New England Journal of Medicine
DOI: 10.1056/NEJMoa1802537
Abstract
BACKGROUND
Tafenoquine, a single-dose therapy for Plasmodium vivax malaria, has been associated with relapse prevention through the clearance of P. vivax parasitemia and hypnozoites, termed “radical cure.”
Single-Dose Tafenoquine to Prevent Relapse of Plasmodium vivax Malaria
The New England Journal of Medicine
DOI: 10.1056/NEJMoa1710775
Abstract
BACKGROUND
Treatment of Plasmodium vivax malaria requires the clearing of asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from the liver (a treatment termed “radical cure”). Tafenoquine is a single-dose 8-aminoquinoline that has recently been registered for the radical cure of P. vivax.
Overcoming challenges to tackle malaria relapse
Half the world’s population lives at risk of the Plasmodium vivax malaria parasite. Once it has infected the human body, it can lie dormant in the liver, hidden from standard antimalarial medicines, and reawaken at regular intervals causing a malaria bouts in the absence of a mosquito bite.
Two positive phase III studies of tafenoquine for the radical cure of Plasmodium vivax malaria published in The New England Journal of Medicine
GSK and Medicines for Malaria Venture (MMV) today announced the publication of positive results from two phase III studies of single-dose tafenoquine for the radical cure (prevention of relapse) of Plasmodium vivax (P. vivax) malaria in The New England Journal of Medicine.
Working to Stop Malaria Relapse for Good
ASTMH Annual Meeting 2018 blog
So far, most medicines for malaria target the pathogenic blood stages and treat the symptoms of the disease. This makes sense. It’s imperative to deal with the immediate suffering of a patient before looking at how to prevent future suffering. Yet, if malaria is to be eradicated, a broader range of medicines with different profiles is needed, not least medicines that can stop the relapse of malaria caused by the Plasmodium vivax parasite.
Kozenis (tafenoquine) approved by the Australian Therapeutic Goods Administration for the radical cure of P. vivax malaria
GSK and Medicines for Malaria Venture (MMV) today announced that the Australian Therapeutic Goods Administration (TGA) has approved single-dose Kozenis (tafenoquine) for the radical cure (prevention of relapse) of Plasmodium vivax (P. vivax) malaria in patients aged 16 years and older who are receiving appropriate antimalarial therapy for the acute P. vivax infection.
Single-dose tafenoquine for radical cure of P. vivax malaria submitted for regulatory approval in Brazil
A Marketing Authorization Application for tafenoquine for radical cure (prevention of relapse) of P. vivax malaria has been submitted by GSK to the Brazilian Health Regulatory Agency (ANVISA) under a priority review, making Brazil the first malaria-endemic country to evaluate the new single dose anti-relapse medicine. A priority review has been granted.
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