Paediatric formulations

Developing new products for vulnerable populations

MMV is dedicated to developing new medicines for vulnerable populations: children and pregnant women, who are at greatest risk of dying from malaria.

Developing better medicines for children

MMV has long recognized that developing better medicines for children helps address the most vulnerable patient population at greatest risk of dying from malaria.

Pyramax® granules

Shin Poong

Product category
  • 3-day cure, artemisinin-based combination therapy (pyronaridine-artesunate)

Therapeutic indication
  • For the treatment of uncomplicated malaria infection caused by P. falciparum or P. vivax in children and infants weighing 5kg to under 20kg

Dosing
  • Once-daily for 3 days

Efficacy
  • 28-day PCR-corrected ACPR* >97%

  • 42-day PCR-corrected ACPR* 90%–95%

Key features
  • Only ACT approved by a stringent regulatory authority for both P. falciparum and P. vivax (blood-stage)
  • No food restrictions

  • Two-year shelf life
  • Child-friendly granules
Challenges
  • WHO Information Note of October 2019 now supports use, purchase and inclusion in national guidelines, yet not formally included in WHO Malaria Treatment Guidelines
Status
  • Included in WHO Essential Medicines List (adults and children)
  • Included in national treatment guidelines of Cameroon, Côte d’Ivoire, Niger and Republic of Congo

  •  Approved in 19 countries
Next milestone
  • Inclusion in WHO Malaria Treatment Guidelines

  •  Publication of multi-country phase IIIb/IV “CANTAM” study results
     
  •  Continued commercial introduction in malaria-endemic countries
Previously
  • Development project team led by University of Iowa

MMV Project Director
  • Adam Aspinall

* ACPR = adequate clinical and parasitological response 

Subscribe to RSS - Paediatric formulations