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Challenges in antimalarial drug discovery [1]

30 Sep 2011

Jeremy N Burrows, Didier Leroy, Julie Lotharius & David Waterson

Future Medicinal Chemistry

DOI: 10.4155/fmc.11.91

Photo: Michael Nivelet/Shuttershock.com

Summary

Malaria is one of the most devastating diseases in the world, affecting almost 225 million people a year, and causing over 780,000 deaths, most of which are children under the age of 5 years. Following the recent call for the eradication of the disease, supported by the WHO, there has been increasing investment into antimalarial drug-discovery projects. These activities are aimed at generating the next generation of molecules focused on the treatment and transmission-blocking of Plasmodium falciparum and Plasmodium vivax endo- and exo-erythrocytic stages of the parasite. This article summarizes the current top-level thinking regarding the prosecution of such endeavors and the disease-specific considerations in project planning.

Read the full article on the Future Science website. [2]


Source URL: https://www.mmv.org/newsroom/publications/challenges-antimalarial-drug-discovery

Links
[1] https://www.mmv.org/newsroom/publications/challenges-antimalarial-drug-discovery
[2] http://www.future-science.com/doi/abs/10.4155/fmc.11.91?journalCode=fmc