MMV launched another initiative to stimulate the discovery of drugs for neglected diseases. The Pathogen Box containing 400 diverse drug-like molecules follows in the footsteps of MMV’s open access Malaria Box and is available for free on request. Each of the compounds has confirmed activity against at least one of the key pathogens that cause some of the most neglected diseases on the planet. The complete set of compounds is ready for dispatch to laboratories around the world to boost drug discovery.
The 400 compounds were hand-picked by experts to provide those with the most promise for drug discovery programmes for neglected diseases such as onchocerciasis, Chagas disease and visceral leishmaniasis, as well as malaria and tuberculosis.
MMV’s experienced medicinal chemists analyzed and triaged active compounds from the European Bioinformatics Institute’s open access database. Meanwhile, partners with expertise in other disease areas were invited to share their insight, molecules and screening platforms. The resulting compound set was reviewed by a Scientific Selection Committee composed of leading figures in medicinal chemistry. MMV then procured fresh solid samples of each compound and thanks to the generous contribution of screening resources by many partners coordinated the confirmation of their biological activity.