Following in the footsteps of MMV’s open access Malaria Box, the Pathogen Box contains 400 diverse drug-like molecules and is available for free on request. As of December 2018, 319 Pathogen Boxes have been shipped to scientists around the world to boost neglected diseases drug discovery. Each of the compounds in the Pathogen Box has confirmed activity against at least one of the key pathogens that cause some of the most neglected diseases on the planet. The complete set of compounds is ready for dispatch to laboratories around the world to boost drug discovery.
The 400 compounds were hand-picked by experts to provide those with the most promise for drug discovery programmes for neglected diseases such as onchocerciasis, Chagas disease and visceral leishmaniasis, as well as malaria and tuberculosis.
MMV’s experienced medicinal chemists analyzed and triaged active compounds from the European Bioinformatics Institute’s open access database. Meanwhile, partners with expertise in other disease areas were invited to share their insight, molecules and screening platforms. The resulting compound set was reviewed by a Scientific Selection Committee composed of leading figures in medicinal chemistry. MMV then procured fresh solid samples of each compound and thanks to the generous contribution of screening resources by many partners coordinated the confirmation of their biological activity.
Updated July 2019