Product vision |
- Uncomplicated malaria treatment and resistance management
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MoA |
- Inhibition of Plasmodium falciparum Acyl-CoA synthetase 10/11
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Key features |
- Novel mode of action and structure
- Highly potent and active against resistant strains
- Fast killing in vitro and in vivo
- Low single dose prediction
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Challenges |
- Low potency on P. vivax and P. knowlesi malaria
- Limited solubility of crystalline material
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Status |
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Next milestone |
- Initiate first-in-human study
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Previously |
- Discovery by GSK with support from the Wellcome Trust
- Full reference name is MMV1582367
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MMV Project Director |
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