Sulfadoxine-pyrimethamine

Product vision
  • Intermittent preventive treatment (TPP-1) during pregnancy (IPTp)
Dosing
  • 1500mg sulfadoxine - 75 mg pyrimethamine (SP; dosed via three tablets), to be given at the beginning of the 2nd trimester of pregnancy at least one month apart until delivery
Efficacy
  • WHO affirmed the effectiveness of IPTp using SP (IPTp-SP), including in areas with SP resistance
  • Estimates indicate that a full course of IPTp-SP decreases the incidence of low birth weight babies by 29%, severe maternal anaemia by 38%, and neonatal mortality by 31%. It is also one of the few health interventions showing reductions in neonatal mortality
Key features
  • Adapted SP packaging to ensure correct use and to improve perception and uptake
Challenges
  • Delivery of IPTp requires a functioning antenatal care platform and access to quality-assured SP
  • Improving quality perceptions about SP and expanding access through community health worker channels can increase IPTp coverage
Status
  • Bioequivalence study in preparation
Next milestone
  • Bioequivalence study start
MMV Project Director
  • Pierre Hugo