Product vision |
- Intermittent preventive treatment (TPP-1) and prophylaxis (TPP-2)
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MoA |
- Interfere with two pathways involved in the biosynthesis of pyrimidines required for nucleic acid replication
- Atovaquone acts against P. falciparum via inhibition of mitochondrial electron transport
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Key features |
- Liver-stage activity and prophylactic efficacy
- Lower doses of atovaquone required in the combination leading to lower cost of goods
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Challenges |
- To obtain comparable bioavailability
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Status |
- Relative bioavailability study between atoguanil and atovaquone-proguanil to be set-up
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Next milestone |
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MMV Project Director |
- Dr Isabelle Borghini Fuhrer
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