Cipargamin

Novartis 

Legend
Product vision

  • Part of single-exposure radical cure

  • Potential for use in severe malaria
MoA

  • PfATP4 inhibitor

     
Key features

  • First validated new molecular target in 20 years; very rapid killing of parasites

  • 75mg human dose stays above Minimal Parasiticidal Concentration for >8 days

  • Potential for transmission-blocking activitiy in a Standard Membrane Feeding Assay
Challenges

  • Safety profile to be further characterized in malaria patient study
Status

  • Completed first phase IIa (short-duration monotherapy PoC in patients) 

  • Phase II study in patients started in February 2018 

  • Parenteral GLP Tox in progress
Next milestone

  • Phase II study completion in 2019/20

  • Initiate parenteral First In Human study in 2019
Previously

  • Names NITD609, KAE609: discovery partnership with Wellcome Trust, Novartis, and the Swiss Tropical and Public Health Institute
MMV Project Director

  • Dr Wiweka Kaszubska (interim)