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Publications

Novel inhibitors of Plasmodium falciparum based on 2,5-disubstituted furans

Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum

Parasitological Clearance Rates and Drug Concentrations of a Fixed Dose Combination of Azithromycin-Chloroquine in Asymptomatic Pregnant Women with Plasmodium Falciparum Parasitemia: An Open-Label, Non-Comparative Study in Sub- Saharan Africa

Stronger research capacity for malaria to counter critical challenges: the Ethiopia experience

Putting children and mothers first

The role of intellectual property in the battle against malaria

Screening the Pathogen Box for Identification of Candida albicans Biofilm Inhibitors

Metabolomics-based screening of the Malaria Box reveals both novel and established mechanisms of action

Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways

Comparison of artesunate–mefloquine and artemether–lumefantrine fixed-dose combinations for treatment of uncomplicated Plasmodium falciparum malaria in children younger than 5 years in sub-Saharan Africa: a randomised, multicentre, phase 4 trial

Identification of a Potential Antimalarial Drug Candidate from a Series of 2‑Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle

Diagnosis and Treatment of Plasmodium vivax Malaria

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling

Pharmacokinetic Interactions between Tafenoquine and Dihydroartemisinin-piperaquine or Artemether-lumefantrine in Healthy Adult Subjects

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

Medicines to protect children from seasonal malaria: what are the options?

A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood stage malaria infection study

Defining the Effectiveness of Antimalarial Chemotherapy: Investigation of the Lag in Parasite Clearance Following Drug Administration

Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways

Open data in drug discovery and development: lessons from malaria

Hit-to-lead studies for the antimalarial tetrahydroisoquinolone carboxanilides

Screening of the ‘Pathogen Box’ identifies an approved pesticide with major anthelmintic activity against the barber's pole worm

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate Dehydrogenase Deficiency: Implications for Use in Malaria Transmission-Blocking Programs

Design, synthesis and biological evaluation of 6-aryl-1,6-dihydro-1,3,5-triazine-2,4-diamines as antiplasmodial antifolates

Extensive shared chemosensitivity between malaria and babesiosis blood-stage parasites

Supporting research in neglected tropical diseases - Lessons from AbbVie’s neglected diseases initiative

Piperaquine Monotherapy of Drug-Susceptible Plasmodium falciparum Infection Results in Rapid Clearance of Parasitemia but Is Followed by the Appearance of Gametocytemia

MMV Annual Report 2015

WHO malaria terminology

Efficacy and Safety of Azithromycin-Chloroquine versus Sulfadoxine-Pyrimethamine for Intermittent Preventive Treatment of Plasmodium falciparum Malaria Infection in Pregnant Women in Africa: An Open-Label, Randomized Trial

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials

Efficacy of OZ439 (artefenomel) against early Plasmodium falciparum blood-stage malaria infection in healthy volunteers

Rectal artesunate stakeholders' meeting report

Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data

Discovering new transmission-blocking antimalarial compounds: Challenges and opportunities

Lead Structure Discovery for Neglected Diseases: Product Development Partnerships Driving Drug Discovery

Rapport de gestion 2015

Pharmacokinetic/pharmacodynamic modelling of the antimalarial effect of Actelion-451840 in an induced blood stage malaria study in healthy subjects

A Public Health Paradox: The women most vulnerable to malaria are the least protected

Identifying antimalarial compounds targeting dihydrofolate reductase-thymidylate synthase (DHFR-TS) by chemogenomic profiling

Tetrahydro-2-naphthyl and 2‑Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

Seasonal Malaria Chemoprevention – A powerful tool to reduce the burden of malaria in young children

Linking murine and human Plasmodium falciparum challenge models in a translational path for antimalarial drug development

Preliminary LC-MS Based Screening for Inhibitors of Plasmodium falciparum Thioredoxin Reductase (PfTrxR) among a Set of Antimalarials from the Malaria Box.

Health Product Research and Development Fund: A Proposal for Financing and Operation

Identification of Plasmodium falciparum specific translation inhibitors from the MMV Malaria Box using a high throughput in vitro translation screen

In vitro screening of the open source MMV malaria box reveals novel compounds with profound activities against Theileria annulata schizonts

Screening of the Open Source Malaria Box Reveals an Early Lead Compound for the Treatment of Alveolar Echinococcosis

Tools and Strategies for Malaria Control and Elimination: What Do We Need to Achieve a Grand Convergence in Malaria?

Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs

Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds

Efficacy and safety of pyronaridine-artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in western Cambodia

Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds

PI4K is a prophylactic, but not radical curative target in Plasmodium vivax-type malaria parasites

Tafenoquine treatment of Plasmodium vivax malaria: suggestive evidence that CYP2D6 reduced metabolism is not associated with relapse in the Phase 2b DETECTIVE trial

MMV's 2016 Advertorial

A chemical susceptibility profile of the Plasmodium falciparum transmission stages by complementary cell-based gametocyte assays

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