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ACS Chemical Biology
Amino Acids
Antimicrobial Agents and Chemotherapy
Bioorganic & Medicinal Chemistry
Chemical Biology & Drug Design
Chemistry of Heterocyclic Compounds
International Journal for Parasitology
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Journal of Biomolecular Screening
Journal of Medicinal Chemistry
Malaria Journal
Molecular Cancer Therapeutics
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PLOS ONE
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SAR and QSAR in Environmental Research
Scientific Reports
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mSphere

Didier Leroy
Jeremy Burrows
Paul Willis
Tim Wells

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Publications

Targeted Phenotypic Screening in Plasmodium falciparum and Toxoplasma gondii Reveals Novel Modes of Action of Medicines for Malaria Venture Malaria Box Molecules

Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents

Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale

The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens

A novel in vitro image-based assay identifies new drug leads for giardiasis

Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum

Metabolomics-based screening of the Malaria Box reveals both novel and established mechanisms of action

Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Extensive shared chemosensitivity between malaria and babesiosis blood-stage parasites

Identifying antimalarial compounds targeting dihydrofolate reductase-thymidylate synthase (DHFR-TS) by chemogenomic profiling

Preliminary LC-MS Based Screening for Inhibitors of Plasmodium falciparum Thioredoxin Reductase (PfTrxR) among a Set of Antimalarials from the Malaria Box.

Identification of Plasmodium falciparum specific translation inhibitors from the MMV Malaria Box using a high throughput in vitro translation screen

In vitro screening of the open source MMV malaria box reveals novel compounds with profound activities against Theileria annulata schizonts

Screening of the Open Source Malaria Box Reveals an Early Lead Compound for the Treatment of Alveolar Echinococcosis

Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds

Antileishmanial Activity of Compounds Derived from the MMV Open Access Box Against Intracellular Leishmania major Amastigotes

Yeast-Based High-Throughput Screens to Identify Novel Compounds Active against Brugia malayi

A semi-automated luminescence based standard membrane feeding assay identifies novel small molecules that inhibit transmission of malaria parasites by mosquitoes

Development and application of a sensitive, phenotypic, high-throughput image-based assay to identify compound activity against Trypanosoma cruzi amastigotes

A simple and predictive phenotypic High Content Imaging assay for Plasmodium falciparum mature gametocytes to identify malaria transmission blocking compounds

Bilayer Effects of Antimalarial Compounds

Identifying rapidly parasiticidal anti-malarial drugs using a simple and reliable in vitro parasite viability fast assay

Diverse chemotypes disrupt ion homeostasis in the malaria parasite

Identification of Novel Ezrin Inhibitors Targeting Metastatic Osteosarcoma by Screening Open Access Malaria Box

Screening and Identification of Inhibitors of Trypanosoma brucei Cathepsin L with Antitrypanosomal Activity

Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination

New insights into novel inhibitors against deoxyhypusine hydroxylase from plasmodium falciparum: compounds with an iron chelating potential

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum Aminopeptidases, M1, M17 and M18

Repurposing of the Open Access Malaria Box for Kinetoplastid Diseases Identifies Novel Active Scaffolds against Trypanosomatids

Yeast-Based High-Throughput Screen Identifies Plasmodium falciparum Equilibrative Nucleoside Transporter 1 Inhibitors That Kill Malaria Parasites

Activities of N,N′-Diarylurea MMV665852 Analogs against Schistosoma mansoni

Prioritization of active antimalarials using structural interaction profile of Plasmodium falciparum enoyl-acyl carrier protein reductase (PfENR)-triclosan derivatives

Quinoxaline-Based Inhibitors of Malarial Protease PfSUB1

A Chemical Rescue Screen Identifies a Plasmodium falciparum Apicoplast Inhibitor Targeting MEP Isoprenoid Precursor Biosynthesis

Identification of MMV Malaria Box Inhibitors of Perkinsus marinus Using an ATP-Based Bioluminescence Assay

A Male and Female Gametocyte Functional Viability Assay To Identify Biologically Relevant Malaria Transmission-Blocking Drugs

A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway

Gametocytocidal Screen Identifies Novel Chemical Classes with Plasmodium falciparum Transmission Blocking Activity

Target evaluation of deoxyhypusine synthase from Theileria parva the neglected animal parasite and its relationship to Plasmodium

Repurposing the Open Access Malaria Box To Discover Potent Inhibitors of Toxoplasma gondii and Entamoeba histolytica

Identification of β-hematin inhibitors in the MMV Malaria Box

Small Molecule Screen for Candidate Antimalarials Targeting Plasmodium Kinesin-5

Identification of an Atg8-Atg3 Protein–Protein Interaction Inhibitor from the Medicines for Malaria Venture Malaria Box Active in Blood and Liver Stage Plasmodium falciparum Parasites

Identification of Cryptosporidium parvum Active Chemical Series by Repurposing the Open Access Malaria Box

Chemical signatures and new drug targets for gametocytocidal drug development

Orally Active Antischistosomal Early Leads Identified from the Open Access Malaria Box

Antiapicoplast and Gametocytocidal Screening To Identify the Mechanisms of Action of Compounds within the Malaria Box

Identification of inhibitors of Plasmodium falciparum gametocyte development

Prediction of the P. falciparum Target Space Relevant to Malaria Drug Discovery

Identification of MMV Malaria Box Inhibitors of Plasmodium falciparum Early-Stage Gametocytes Using a Luciferase-Based High-Throughput Assay

Chemical profiling of deoxyhypusine hydroxylase inhibitors for antimalarial therapy

The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases

The Malaria Box: a catalyst for drug discovery