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Authors (MMV)
Didier Leroy
Jeremy Burrows
Paul Willis
Tim Wells
Search
58 found
An Exclusive Computational Insight toward Molecular Mechanism of MMV007571, A Multitarget Inhibitor of
Plasmodium falciparum
17 Dec 2019
The relative rate of kill of the MMV Malaria Box compounds provides links to the mode of antimalarial action and highlights scaffolds of medicinal chemistry interest
19 Nov 2019
Discovering the
in vitro
potent inhibitors against Babesia and Theileria parasites by repurposing the Malaria Box: A review
21 Sep 2019
Diverse Chemical Compounds Target
Plasmodium falciparum
Plasma Membrane Lipid Homeostasis
14 Jan 2019
Targeted Phenotypic Screening in Plasmodium falciparum and
Toxoplasma gondii
Reveals Novel Modes of Action of Medicines for Malaria Venture Malaria Box Molecules
17 Jan 2018
Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents
14 Feb 2017
Substrate-analogous inhibitors exert antimalarial action by targeting the
Plasmodium
lactate transporter PfFNT at nanomolar scale
08 Feb 2017
The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens
08 Feb 2017
A novel in vitro image-based assay identifies new drug leads for giardiasis
27 Jan 2017
Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of
Plasmodium falciparum
22 Nov 2016
Metabolomics-based screening of the Malaria Box reveals both novel and established mechanisms of action
21 Oct 2016
Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways
21 Oct 2016
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond
28 Jul 2016
Extensive shared chemosensitivity between malaria and babesiosis blood-stage parasites
22 Jul 2016
Identifying antimalarial compounds targeting dihydrofolate reductase-thymidylate synthase (DHFR-TS) by chemogenomic profiling
02 May 2016
Preliminary LC-MS Based Screening for Inhibitors of Plasmodium falciparum Thioredoxin Reductase (PfTrxR) among a Set of Antimalarials from the Malaria Box.
28 Mar 2016
Identification of Plasmodium falciparum specific translation inhibitors from the MMV Malaria Box using a high throughput in vitro translation screen
17 Mar 2016
In vitro screening of the open source MMV malaria box reveals novel compounds with profound activities against Theileria annulata schizonts
14 Mar 2016
Screening of the Open Source Malaria Box Reveals an Early Lead Compound for the Treatment of Alveolar Echinococcosis
11 Mar 2016
Biochemical Screening of Five Protein Kinases from
Plasmodium falciparum
against 14,000 Cell-Active Compounds
02 Mar 2016
Antileishmanial Activity of Compounds Derived from the MMV Open Access Box Against Intracellular Leishmania major Amastigotes
03 Feb 2016
Yeast-Based High-Throughput Screens to Identify Novel Compounds Active against Brugia malayi
26 Jan 2016
A semi-automated luminescence based standard membrane feeding assay identifies novel small molecules that inhibit transmission of malaria parasites by mosquitoes
21 Dec 2015
Development and application of a sensitive, phenotypic, high-throughput image-based assay to identify compound activity against Trypanosoma cruzi amastigotes
01 Dec 2015
A simple and predictive phenotypic High Content Imaging assay for
Plasmodium falciparum
mature gametocytes to identify malaria transmission blocking compounds
10 Nov 2015
Bilayer Effects of Antimalarial Compounds
09 Nov 2015
Identifying rapidly parasiticidal anti-malarial drugs using a simple and reliable in vitro parasite viability fast assay
05 Nov 2015
Diverse chemotypes disrupt ion homeostasis in the malaria parasite
15 Sep 2015
Identification of Novel Ezrin Inhibitors Targeting Metastatic Osteosarcoma by Screening Open Access Malaria Box
10 Sep 2015
Screening and Identification of Inhibitors of Trypanosoma brucei Cathepsin L with Antitrypanosomal Activity
27 Aug 2015
Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination
22 May 2015
New insights into novel inhibitors against deoxyhypusine hydroxylase from plasmodium falciparum: compounds with an iron chelating potential
26 Feb 2015
Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum Aminopeptidases, M1, M17 and M18
20 Feb 2015
Repurposing of the Open Access Malaria Box for Kinetoplastid Diseases Identifies Novel Active Scaffolds against Trypanosomatids
17 Feb 2015
Yeast-Based High-Throughput Screen Identifies Plasmodium falciparum Equilibrative Nucleoside Transporter 1 Inhibitors That Kill Malaria Parasites
20 Jan 2015
Activities of N,N′-Diarylurea MMV665852 Analogs against Schistosoma mansoni
12 Jan 2015
Prioritization of active antimalarials using structural interaction profile of Plasmodium falciparum enoyl-acyl carrier protein reductase (PfENR)-triclosan derivatives
08 Jan 2015
Quinoxaline-Based Inhibitors of Malarial Protease PfSUB1
16 Dec 2014
A Chemical Rescue Screen Identifies a Plasmodium falciparum Apicoplast Inhibitor Targeting MEP Isoprenoid Precursor Biosynthesis
03 Nov 2014
Identification of MMV Malaria Box Inhibitors of Perkinsus marinus Using an ATP-Based Bioluminescence Assay
22 Oct 2014
A Male and Female Gametocyte Functional Viability Assay To Identify Biologically Relevant Malaria Transmission-Blocking Drugs
29 Sep 2014
A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway
31 Aug 2014
Gametocytocidal Screen Identifies Novel Chemical Classes with Plasmodium falciparum Transmission Blocking Activity
26 Aug 2014
Target evaluation of deoxyhypusine synthase from Theileria parva the neglected animal parasite and its relationship to Plasmodium
01 Aug 2014
Repurposing the Open Access Malaria Box To Discover Potent Inhibitors of Toxoplasma gondii and Entamoeba histolytica
21 Jul 2014
Identification of β-hematin inhibitors in the MMV Malaria Box
15 Jun 2014
Small Molecule Screen for Candidate Antimalarials Targeting Plasmodium Kinesin-5
06 Jun 2014
Identification of an Atg8-Atg3 Protein–Protein Interaction Inhibitor from the Medicines for Malaria Venture Malaria Box Active in Blood and Liver Stage Plasmodium falciparum Parasites
01 May 2014
Identification of Cryptosporidium parvum Active Chemical Series by Repurposing the Open Access Malaria Box
24 Feb 2014
Chemical signatures and new drug targets for gametocytocidal drug development
17 Jan 2014
Orally Active Antischistosomal Early Leads Identified from the Open Access Malaria Box
09 Jan 2014
Antiapicoplast and Gametocytocidal Screening To Identify the Mechanisms of Action of Compounds within the Malaria Box
18 Nov 2013
Identification of inhibitors of Plasmodium falciparum gametocyte development
11 Nov 2013
Prediction of the P. falciparum Target Space Relevant to Malaria Drug Discovery
17 Oct 2013
Identification of MMV Malaria Box Inhibitors of Plasmodium falciparum Early-Stage Gametocytes Using a Luciferase-Based High-Throughput Assay
23 Sep 2013
Chemical profiling of deoxyhypusine hydroxylase inhibitors for antimalarial therapy
13 Aug 2013
The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases
17 Jun 2013
The Malaria Box: a catalyst for drug discovery
10 Oct 2012