Publications

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69 found

'Erythritol', a safe natural sweetener exhibits multi-stage anti-malarial activity by permeating into Plasmodium falciparum through aquaglyceroporin channel.

01 Nov 2022
Scientific article

Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362

10 Oct 2022
Scientific article

Contribute to defeating malaria

20 Sep 2022
Advocacy article, External publication

Optimized pyridazinone nutrient channel inhibitors are potent and specific antimalarial leads

07 Jul 2022
Scientific article

Volunteer infection studies accelerate the clinical development of novel drugs against malaria

02 Mar 2022
Scientific article

Assessing risks of Plasmodium falciparum resistance to select next-generation antimalarials

01 Aug 2021
Scientific article

MalDA, Accelerating Malaria Drug Discovery

01 Jun 2021
Scientific article

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series

13 May 2021
Scientific article

Actives from MMV Open Access Boxes? A suggested way forward

22 Apr 2021
Scientific article

MAIP: a web service for predicting blood-stage malaria inhibitors

22 Feb 2021
Scientific article

Targeting Plasmepsins-An Achilles' Heel of the Malaria Parasite

08 Apr 2020
Scientific article

An in vitro toolbox to accelerate anti-malarial drug discovery and development

13 Jan 2020
Scientific article

Ivermectin as a novel complementary malaria control tool to reduce incidence and prevalence: a modelling study

13 Jan 2020
Scientific article

The Development Process for Discovery and Clinical Advancement of Modern Antimalarials

12 Dec 2019
Scientific article

Blocking Plasmodium Development in Mosquitoes: A Powerful New Approach for Expanding Malaria Control Efforts.

01 Oct 2019
Scientific article

Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone

03 May 2019
Scientific article

Partnering to fight malaria in India: Past, present and future

05 Mar 2019
Scientific article

A discovery and development roadmap for new endectocidal transmission-blocking agents in malaria

10 Dec 2018
Scientific article

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

07 Dec 2018
Scientific article

Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome

21 Nov 2018
Scientific article

Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria

11 Nov 2018
Scientific article

Evaluation of Current and Emerging Antimalarial Medicines for Inhibition of Toxoplasma gondii Growth in Vitro

10 Aug 2018
Scientific article

Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγnull Mouse Model of Malaria

17 Apr 2018
Scientific article

Modelling mosquito infection at natural parasite densities identifies drugs targeting

15 Dec 2017
Scientific article

The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold

14 Aug 2017
Scientific article

Malaria

03 Aug 2017
Scientific article

Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus

31 May 2017
Pathogen Box article, Scientific article

Parasite physiology: No longer lost in translation

25 May 2017
Scientific article

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

26 Apr 2017
Scientific article

Shared Consensus Machine Learning Models for Predicting Blood Stage Malaria Inhibition

27 Mar 2017
Scientific article

Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model

23 Feb 2017
Scientific article

Arylmethylamino steroids as antiparasitic agents

17 Feb 2017
Scientific article

New developments in anti-malarial target candidate and product profiles

13 Jan 2017
Scientific article

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling

04 Oct 2016
Scientific article

Open data in drug discovery and development: lessons from malaria

12 Aug 2016
Scientific article

Lead Structure Discovery for Neglected Diseases: Product Development Partnerships Driving Drug Discovery

13 May 2016
Scientific article

Tetrahydro-2-naphthyl and 2‑Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

29 Apr 2016
Scientific article

A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments

08 Oct 2015
Scientific article

Hit and lead criteria in drug discovery for infectious diseases of the developing world

05 Oct 2015
Scientific article

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

16 Jul 2015
Scientific article

Killing the hypnozoite – drug discovery approaches to prevent relapse in Plasmodium vivax

06 May 2015
Scientific article

Malaria runs rings round artemisinin

30 Apr 2015
Scientific article

Subtle changes in endochin-like quinolone (ELQ) structure alter site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum

20 Jan 2015
Scientific article

Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum

25 Nov 2014
Scientific article

Defining the biology component of the drug discovery strategy for malaria eradication

18 Aug 2014
Scientific article

Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum

28 May 2014
Scientific article

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

07 May 2014
Scientific article

The role of modern drug discovery in the fight against neglected and tropical diseases

23 Apr 2014
Scientific article

Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers

10 Apr 2014
Scientific article

In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models

15 Nov 2013
Scientific article

Advancing antimalarial drug research through open source initiatives

24 Jul 2013
Advocacy article

The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases

17 Jun 2013
Malaria Box article, Scientific article

The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases

17 Jun 2013
Scientific article

Designing the next generation of medicines for malaria control and eradication

06 Jun 2013
Scientific article

Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

20 Mar 2013
Scientific article

Antimalarial drug discovery: where next?

12 Dec 2012
Scientific article

The Malaria Box: a catalyst for drug discovery

10 Oct 2012
Malaria Box article, Scientific article

The global pipeline of new medicines for the control and elimination of malaria

07 Sep 2012
Scientific article

Identification and In-Vitro ADME Assessment of a Series of Novel Anti-Malarial Agents Suitable for Hit-to-Lead Chemistry

28 May 2012
Scientific article

A Divergent SAR Study Allows Optimization of a Potent 5-HT2c Inhibitor to a Promising Antimalarial Scaffold

09 Feb 2012
Scientific article

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