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Cristina Donini
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Stephan Duparc
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Sylvie Fonteilles-Drabek
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Zaira Rizopoulos
Search
69 found
'Erythritol', a safe natural sweetener exhibits multi-stage anti-malarial activity by permeating into
Plasmodium falciparum
through aquaglyceroporin channel.
01 Nov 2022
Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362
10 Oct 2022
Contribute to defeating malaria
20 Sep 2022
Optimized pyridazinone nutrient channel inhibitors are potent and specific antimalarial leads
07 Jul 2022
Volunteer infection studies accelerate the clinical development of novel drugs against malaria
02 Mar 2022
Assessing risks of
Plasmodium falciparum
resistance to select next-generation antimalarials
01 Aug 2021
MalDA, Accelerating Malaria Drug Discovery
01 Jun 2021
Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series
13 May 2021
Actives from MMV Open Access Boxes? A suggested way forward
22 Apr 2021
MAIP: a web service for predicting blood-stage malaria inhibitors
22 Feb 2021
Targeting Plasmepsins-An Achilles' Heel of the Malaria Parasite
08 Apr 2020
An
in vitro
toolbox to accelerate anti-malarial drug discovery and development
13 Jan 2020
Ivermectin as a novel complementary malaria control tool to reduce incidence and prevalence: a modelling study
13 Jan 2020
The Development Process for Discovery and Clinical Advancement of Modern Antimalarials
12 Dec 2019
Blocking
Plasmodium
Development in Mosquitoes: A Powerful New Approach for Expanding Malaria Control Efforts.
01 Oct 2019
Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone
03 May 2019
Partnering to fight malaria in India: Past, present and future
05 Mar 2019
A discovery and development roadmap for new endectocidal transmission-blocking agents in malaria
10 Dec 2018
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials
07 Dec 2018
Target Validation and Identification of Novel Boronate Inhibitors of the
Plasmodium falciparum
Proteasome
21 Nov 2018
Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria
11 Nov 2018
Evaluation of Current and Emerging Antimalarial Medicines for Inhibition of
Toxoplasma gondii
Growth
in Vitro
10 Aug 2018
Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγnull Mouse Model of Malaria
17 Apr 2018
Modelling mosquito infection at natural parasite densities identifies drugs targeting
15 Dec 2017
The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold
14 Aug 2017
Malaria
03 Aug 2017
Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus
31 May 2017
Parasite physiology: No longer lost in translation
25 May 2017
Antimalarial efficacy of MMV390048, an inhibitor of
Plasmodium
phosphatidylinositol 4-kinase
26 Apr 2017
Shared Consensus Machine Learning Models for Predicting Blood Stage Malaria Inhibition
27 Mar 2017
Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and
in Vivo
Oral Efficacy in a Mouse Model
23 Feb 2017
Arylmethylamino steroids as antiparasitic agents
17 Feb 2017
New developments in anti-malarial target candidate and product profiles
13 Jan 2017
Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling
04 Oct 2016
Open data in drug discovery and development: lessons from malaria
12 Aug 2016
Lead Structure Discovery for Neglected Diseases: Product Development Partnerships Driving Drug Discovery
13 May 2016
Tetrahydro-2-naphthyl and 2‑Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity
29 Apr 2016
A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments
08 Oct 2015
Hit and lead criteria in drug discovery for infectious diseases of the developing world
05 Oct 2015
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria
16 Jul 2015
Killing the hypnozoite – drug discovery approaches to prevent relapse in
Plasmodium vivax
06 May 2015
Malaria runs rings round artemisinin
30 Apr 2015
Subtle changes in endochin-like quinolone (ELQ) structure alter site of inhibition within the cytochrome bc1 complex of
Plasmodium falciparum
20 Jan 2015
Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic
Plasmodium falciparum
25 Nov 2014
Defining the biology component of the drug discovery strategy for malaria eradication
18 Aug 2014
Screening and hit evaluation of a chemical library against blood-stage
Plasmodium falciparum
28 May 2014
Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of
Plasmodium falciparum
Dihydroorotate Dehydrogenase Inhibitors
07 May 2014
The role of modern drug discovery in the fight against neglected and tropical diseases
23 Apr 2014
Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers
10 Apr 2014
In vitro
and
in vivo
characterization of the antimalarial lead compound SSJ-183 in Plasmodium models
15 Nov 2013
Advancing antimalarial drug research through open source initiatives
24 Jul 2013
The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases
17 Jun 2013
The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases
17 Jun 2013
Designing the next generation of medicines for malaria control and eradication
06 Jun 2013
Quinolone-3-Diarylethers: A New Class of Antimalarial Drug
20 Mar 2013
Antimalarial drug discovery: where next?
12 Dec 2012
The Malaria Box: a catalyst for drug discovery
10 Oct 2012
The global pipeline of new medicines for the control and elimination of malaria
07 Sep 2012
Identification and In-Vitro ADME Assessment of a Series of Novel Anti-Malarial Agents Suitable for Hit-to-Lead Chemistry
28 May 2012
A Divergent SAR Study Allows Optimization of a Potent 5-HT2c Inhibitor to a Promising Antimalarial Scaffold
09 Feb 2012
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