Publications

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24 found

Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362

10 Oct 2022
Scientific article

Preliminary Structure-Activity Relationship Study of the MMV Pathogen Box Compound MMV675968 (2,4-Diaminoquinazoline) Unveils Novel Inhibitors of Trypanosoma brucei brucei

04 Oct 2022
Scientific article

Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2

21 Sep 2022
Scientific article

Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a nano luciferase reporter read-out

21 Jul 2022
Scientific article

Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development

25 Mar 2022
Scientific article

Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials

26 Aug 2021
Scientific article

Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity

08 Aug 2021
Scientific article

The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance

05 Jul 2021
Scientific article

Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors

11 Jun 2021
Scientific article

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series

13 May 2021
Scientific article

Actives from MMV Open Access Boxes? A suggested way forward

22 Apr 2021
Scientific article

Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum

11 Mar 2021
Scientific article

Escaping from Flatland: Antimalarial Activity of sp3-Rich Bridged Pyrrolidine Derivatives

10 Nov 2020
Scientific article

The Development Process for Discovery and Clinical Advancement of Modern Antimalarials

12 Dec 2019
Scientific article

Early Antischistosomal Leads Identified from in Vitro and in Vivo Screening of the Medicines for Malaria Venture Pathogen Box

16 Nov 2018
Pathogen Box article, Scientific article

Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against Schistosoma mansoni

15 May 2018
Scientific article

Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma

26 Apr 2018
Pathogen Box article, Scientific article

Screening of TB Actives for Activity against Nontuberculous Mycobacteria Delivers High Hit Rates

15 Aug 2017
Pathogen Box article, Scientific article

In vitro screening of the open source pathogen box identifies novel compounds with profound activities against Neospora caninum

25 Jul 2017
Pathogen Box article, Scientific article

Screening of the ‘Stasis Box’ identifies two kinase inhibitors under pharmaceutical development with activity against Haemonchus contortus

05 Jul 2017
Scientific article

Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus

31 May 2017
Pathogen Box article, Scientific article

Susceptibility Testing of Medically Important Parasites

26 Apr 2017
Scientific article

Identifying the need for new drugs – Opening doors

20 Mar 2017
Scientific article

Screening of the ‘Pathogen Box’ identifies an approved pesticide with major anthelmintic activity against the barber's pole worm

28 Jul 2016
Pathogen Box article, Scientific article