Targeting Plasmepsins-An Achilles' Heel of the Malaria Parasite

08 Apr 2020

Burrows JN, Soldati-Favre D

Cell Host & Microbe
PMID: 32272073

Doi: 10.1016/j.chom.2020.03.015

Photo: BrianAJackson/iStock

Recently, two Plasmodium aspartyl proteases were identified as druggable targets impacting parasite survival. In this issue of Cell Host & Microbe, Favuzza et al. describe the optimization of a compound series acting on both targets, heralding the prospect of a new class of antimalarials for clinical studies.

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