Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery

26 Oct 2018

Clinton G. L. Veale  and  Heinrich C. Hoppe


DOI: 10.1039/c8md00319j


This study aimed to uncover new starting points for anti-trypansomal drug discovery through the screening of the Pathogen Box against Trypanosoma brucei brucei. Our study identified compounds 35, 39, 46, 53 and 56 whose activity and selectivity highlighted them as promising candidates with potential for further study and optimisation.

Read the full article on the Royal Society of Chemistry website.