Quinoxaline-Based Inhibitors of Malarial Protease PfSUB1

16 Dec 2014

S. S. Kher, M. Penzo, S. Fulle, J. P. Ebejer, P. W. Finn,M. J. Blackman, and A. Jirgensons.

Chemistry of Heterocyclic Compounds

DOI 10.1007/s10593-014-1610-4.

Abstract

2,3-Bis(phenylamino)quinoxalines have been identified as a novel class of malarial protease PfSUB1 inhibitors by screening of Malaria Box compounds. The synthesis of analog series and investigation of their inhibitory activity provided preliminary structure–activity relationship to create in silico models for binding of these compounds into the active site of PfSUB1.

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