Quinolones, such as the antimalarial atovaquone, are inhibitors of the malarial mitochondrial cytochrome complex, a target critical to the survival of both liver- and blood-stage parasites, making these drugs useful as both prophylaxis and treatment. Recently, several derivatives of endochin have been optimized to produce novel quinolones that are active and in animal models. While these quinolones exhibit potent activity against and, their activity against the zoonotic agent is unknown. We screened several of these novel endochin-like quinolones (ELQs) for their activity against and compared this with their activity against tested under identical conditions.
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