Novel Endochin-Like Quinolones Exhibit Potent In Vitro Activity against Plasmodium knowlesi but Do Not Synergize with Proguanil

21 Apr 2020

van Schalkwyk DA, Riscoe MK, Pou S, Winter RW, Nilsen A, Duffey M, Moon RW, Sutherland CJ

Antimicrobial Agents and Chemotherapy
PMID: 32094134

Doi: 10.1128/AAC.02549-19

Photo: Gerasimov174

Quinolones, such as the antimalarial atovaquone, are inhibitors of the malarial mitochondrial cytochrome complex, a target critical to the survival of both liver- and blood-stage parasites, making these drugs useful as both prophylaxis and treatment. Recently, several derivatives of endochin have been optimized to produce novel quinolones that are active and in animal models. While these quinolones exhibit potent activity against and, their activity against the zoonotic agent is unknown. We screened several of these novel endochin-like quinolones (ELQs) for their activity against and compared this with their activity against tested under identical conditions. 

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