Extensive shared chemosensitivity between malaria and babesiosis blood-stage parasites

22 Jul 2016

By Paul, Aditya S.; Moreira, Cristina K.; Elsworth, Brendan; Allred, David R.; Duraisingh, Manoj T.

Antimicrobial Agents and Chemotherapy

doi: 10.1128/AAC.00928-16


The apicomplexan hemoprotozoan parasites that cause malaria and babesiosis each invade and proliferate within erythrocytes. To assess the potential for common antiparasitic treatments, we measured the sensitivities of multiple species of Plasmodium and Babesia parasites to the chemically diverse collection of antimalarial compounds in the Malaria Box library. We observed that these parasites share sensitivity to a large fraction of the same inhibitors, and identified compounds with strong babesiacidal activity.

Read the full article on the Antimicrobial Agents and Chemotherapy website.