Discovery of Anti-Amoebic Inhibitors from Screening the MMV Pandemic Response Box on Balamuthia mandrillaris, Naegleria fowleri, and Acanthamoeba castellanii

16 Jun 2020

Rice CA, Troth EV, Russell AC, Kyle DE

Pathogens (Basel, Switzerland)
PMID: 32560115

Doi: pii: E476. doi: 10.3390/pathogens9060476

Photo: BrianAJackson

Pathogenic free-living amoebae  Balamuthia mandrillarisNaegleria fowleri, and several Acanthamoeba species are the etiological agents of severe brain diseases, with case mortality rates > 90%. A number of constraints including misdiagnosis and partially effective treatments lead to these high fatality rates. The unmet medical need is for rapidly acting, highly potent new drugs to reduce these alarming mortality rates. Herein, we report the discovery of new drugs as potential anti-amoebic agents. We used the CellTiter-Glo 2.0 high-throughput screening methods to screen the Medicines for Malaria Ventures (MMV) Pandemic Response Box in a search for new active chemical scaffolds.