Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic

04 Aug 2017

Benjamin Blasco, Didier Leroy & David A. Fidock

Nature Medicine

doi: 10.1038/nm.4381

Abstract

The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria. However, several Southeast Asian countries have now reported the emergence of parasites that have decreased susceptibility to artemisinin (ART) derivatives and ACT partner drugs, resulting in increasing rates of treatment failures. Here we review recent advances in understanding how antimalarials act and how resistance develops, and discuss new strategies for effectively combatting resistance, optimizing treatment and advancing the global campaign to eliminate malaria.

View the full article on Nature Medicine's website.