Medicines for Malaria Venture’s Adam Aspinall discusses patient adherence to antimalarials and the pipeline of future medicines set to improve it
Adherence, compliance, concordance – whichever term you prefer, all refer to the extent to which patients take their medication as prescribed.1,2 The three key elements involve taking a medicine at the right dose, the correct dosing frequency and for the recommended treatment duration.3 Failure to take medicines as recommended has negative consequences; for some therapeutic areas, such as the treatment of musculo-skeletal disorders with non-steroidal anti-inflammatory drugs, poor adherence may ‘only’ result in inadequate symptom control. For diseases such as uncomplicated malaria, the consequences can be far more serious; sub-optimal adherence has been associated with treatment failure, severe malaria and death.1,3,4 Continue reading....
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1. Aronson J. Compliance, concordance, adherence. Br J Clin Pharmacol 2007; 63(4): 383-384.
2. Van den Bemt B, Zwikker H, Van den Ende C. Medication Adherence in Patients With Rheumatoid Arthritis: A Critical Appraisal of the Existing Literature: Adherence Terminology: Adherence, Compliance and
Concordance. Expert Rev Clin Immunol 2012; 8(4): 337-351.
3. Bruxvoort K, et al. How Patients Take Malaria Treatment: A Systematic Review of the Literature on Adherence to Antimalarial Drugs. PLOS One 2014; 9(1).
4. Siddiqui M & Ruby, et al. Adherence to Artemisinin Combination Therapy for the treatment of uncomplicated malaria in the Democratic Republic of the Congo. F1000 Research 2015; 4(51).