Adherence to antimalarial treatments in the real world – does it really matter?

19 Oct 2015
Africa Health

Medicines for Malaria Venture’s Adam Aspinall discusses patient adherence to antimalarials and the pipeline of future medicines set to improve it

 Adherence, compliance, concordance – whichever term you prefer, all refer to the extent to which patients take their medication as prescribed.1,2 The three key elements involve taking a medicine at the right dose, the correct dosing frequency and for the recommended treatment duration.3 Failure to take medicines as recommended has negative consequences; for some therapeutic areas, such as the treatment of musculo-skeletal disorders with non-steroidal anti-inflammatory drugs, poor adherence may ‘only’ result in inadequate symptom control. For diseases such as uncomplicated malaria, the consequences can be far more serious; sub-optimal adherence has been associated with treatment failure, severe malaria and death.1,3,4  Continue reading....

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1. Aronson J. Compliance, concordance, adherence. Br J Clin Pharmacol 2007; 63(4): 383-384.
2. Van den Bemt B, Zwikker H, Van den Ende C. Medication Adherence in Patients With Rheumatoid Arthritis: A Critical Appraisal of the Existing Literature: Adherence Terminology: Adherence, Compliance and
Concordance. Expert Rev Clin Immunol 2012; 8(4): 337-351.
3. Bruxvoort K, et al. How Patients Take Malaria Treatment: A Systematic Review of the Literature on Adherence to Antimalarial Drugs. PLOS One 2014; 9(1).
4. Siddiqui M & Ruby, et al. Adherence to Artemisinin Combination Therapy for the treatment of uncomplicated malaria in the Democratic Republic of the Congo. F1000 Research 2015; 4(51).