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Publications

Annual Report 2021

Rapport de gestion 2021

Protecting Children: 10 Years of Seasonal Malaria Chemoprevention

An innovative study design with intermittent dosing to generate a GLP-regulatory package in preclinical species for long lasting molecule M5717, inhibitor of Plasmodium eukaryotic translation elongation factor 2

Transmission-blocking drugs for malaria elimination

Opinion: In support of an integrated approach to defeat malaria

Invest in malaria and NTDs to fight future disease outbreaks

Malaria during early childhood: Intermittent Preventive Treatment

Malarial PI4K inhibitor induced diaphragmatic hernias in rat: Potential link with mammalian kinase inhibition

Re-orienting anti-malarial drug development to better serve pregnant women

Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development

Impact of the malaria comprehensive case management programme in Odisha, India

Temporal distribution of Plasmodium falciparum recrudescence following artemisinin-based combination therapy: an individual participant data meta-analysis

A call to scale up preventive malaria treatment for pregnant women in sub-Saharan Africa

Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data

Volunteer infection studies accelerate the clinical development of novel drugs against malaria

Safety, pharmacokinetics, and antimalarial activity of the novel triaminopyrimidine ZY-19489: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study, pilot food-effect study, and volunteer infection study

Efficient simulation of clinical target response surfaces

Therapeutic efficacy of antimalarial drugs targeting DosRS signaling in Mycobacterium abscessus

Active Pharmacovigilance for Primaquine Radical Cure of Plasmodium vivax Malaria in Odisha, India

Malaria in the time of COVID: Through the looking glass

IMI European Lead Factory - democratizing access to high-throughput screening

World Malaria Report 2021

Tafenoquine exposure assessment, safety, and relapse prevention efficacy in children with Plasmodium vivax malaria: open-label, single-arm, non-comparative, multicentre, pharmacokinetic bridging, phase II trial

Host-directed therapy, an untapped opportunity for antimalarial intervention

Eliminating malaria in southeast Asia requires more attention on adolescent girls

Increasing access to malaria interventions for adolescent girls is an important step toward malaria elimination

Probing the distinct chemosensitivity of Plasmodium vivax liver stage parasites and demonstration of 8-aminoquinoline radical cure activity in vitro

Best of British: How British-backed science can accelerate the end of malaria

New Scalable Synthetic Routes to ELQ-300, ELQ-316, and Other Antiparasitic Quinolones

Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates

MMV at a glance

Prioritization of Molecular Targets for Antimalarial Drug Discovery

Decreased Susceptibility to Dihydrofolate Reductase Inhibitors Associated With Genetic Polymorphisms in Ugandan Plasmodium falciparum Isolates

Unanticipated CNS Safety Signal in a Placebo-Controlled, Randomized Trial of Co-Administered Atovaquone-Proguanil and Amodiaquine.

Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials

Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity

Entamoeba Chitinase is Required for Mature Round Cyst Formation

Assessing risks of Plasmodium falciparum resistance to select next-generation antimalarials

Ex vivo susceptibility to new antimalarial agents differs among human-infecting Plasmodium species

The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance

Persistent Submicroscopic Plasmodium falciparum Parasitemia 72 Hours after Treatment with Artemether-Lumefantrine Predicts 42-Day Treatment Failure in Mali and Burkina Faso

Plasmodium malariae and Plasmodium falciparum comparative susceptibility to antimalarial drugs in Mali

Cross-resistance of the chloroquine-derivative AQ-13 with amodiaquine in Cambodian Plasmodium falciparum isolates

Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439

The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance

Annual Report 2020

Rapport de gestion 2020

Seeking an optimal dosing regimen for OZ439/DSM265 combination therapy for treating uncomplicated falciparum malaria

Gender issues must not be an afterthought in global health research

Pyronaridine-artesunate real-world safety, tolerability, and effectiveness in malaria patients in 5 African countries: A single-arm, open-label, cohort event monitoring study

Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors

A Molecular Signature for Il-10-Producing Th1 Cells in Protozoan Parasitic Diseases

MalDA, Accelerating Malaria Drug Discovery

Perception of Malaria Chemoprevention Interventions in Infants and Children in Eight Sub-Saharan African Countries: An End User Perspective Study

A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria

Participatory research for the development of information, education and communication tools to promote intermittent preventive treatment of malaria in pregnancy in the Democratic Republic of the Congo, Nigeria and Mozambique

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series

Efficacy, Safety and Tolerability of Pyronaridine-artesunate in Asymptomatic Malaria-infected Individuals: a Randomized Controlled Trial

Longitudinal study based on a safety registry for malaria patients treated with artenimol-piperaquine in six European countries

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