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Publications

Contribute to defeating malaria

Fighting the Scourge of Fake Medicines: Global Fund Replenishment is Moment of Truth

Tumor distribution by quantitative mass spectrometry imaging of the inhibitor of apoptosis protein antagonist xevinapant in patients with resectable squamous cell carcinoma of the head and neck (EudraCT Number: 2014-004655-31)

Susceptibilities of Ugandan plasmodium falciparum isolates to proteasome inhibitors

Fighting malaria from Geneva

Development of a biomarker to monitor target engagement after treatment with dihydroorotate dehydrogenase inhibitors

Safety, tolerability, and parasite clearance kinetics in controlled human malaria infection after direct venous inoculation of plasmodium falciparum sporozoites: a model for evaluating new blood-stage antimalarial drugs

Seasonal Malaria Chemoprevention implementation: Effect on malaria incidence and immunity in a context of expansion of P. falciparum resistant genotypes with potential reduction of the effectiveness in sub-Saharan Africa

Monoclonal Antibodies for Malaria

Opinion: Preventing malaria in pregnancy to sow seeds of success in Africa

Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a nano luciferase reporter read-out

Optimized pyridazinone nutrient channel inhibitors are potent and specific antimalarial leads

Clinical and population-based study design considerations to accelerate the investigation of new antiretrovirals during pregnancy

Implementation and continued validation of the malaria Plasmodium falciparum lactate dehydrogenase-based colorimetric assay for use in antiplasmodial drug screening

Annual Report 2021

Rapport de gestion 2021

Stakeholder perceptions on the deployment of multiple first-line therapies for uncomplicated malaria: a qualitative study in the health district of Kaya, Burkina Faso

Parasite Viability as a Measure of In Vivo Drug Activity in Preclinical and Early Clinical Antimalarial Drug Assessment

Protecting Children: 10 Years of Seasonal Malaria Chemoprevention

Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy

Effectiveness of pyronaridine-artesunate against Plasmodium malariae, Plasmodium ovale spp, and mixed-Plasmodium infections: a post-hoc analysis of the CANTAM-Pyramax trial

Attitudes, practices, and determinants of community care-seeking behaviours for fever/malaria episodes in the context of the implementation of multiple first-line therapies for uncomplicated malaria in the health district of Kaya, Burkina Faso

An innovative study design with intermittent dosing to generate a GLP-regulatory package in preclinical species for long lasting molecule M5717, inhibitor of Plasmodium eukaryotic translation elongation factor 2

Transmission-blocking drugs for malaria elimination

Opinion: In support of an integrated approach to defeat malaria

Invest in malaria and NTDs to fight future disease outbreaks

Malaria during early childhood: Intermittent Preventive Treatment

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

Malarial PI4K inhibitor induced diaphragmatic hernias in rat: Potential link with mammalian kinase inhibition

Re-orienting anti-malarial drug development to better serve pregnant women

Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development

Temporal distribution of Plasmodium falciparum recrudescence following artemisinin-based combination therapy: an individual participant data meta-analysis

Impact of the malaria comprehensive case management programme in Odisha, India

Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria

A call to scale up preventive malaria treatment for pregnant women in sub-Saharan Africa

Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data

Volunteer infection studies accelerate the clinical development of novel drugs against malaria

Safety, pharmacokinetics, and antimalarial activity of the novel triaminopyrimidine ZY-19489: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study, pilot food-effect study, and volunteer infection study

Enantiopure Benzofuran-2-carboxamides of 1-Aryltetrahydro-β-carbolines Are Potent Antimalarials In Vitro

Efficient simulation of clinical target response surfaces

Malaria Box-Inspired Discovery of N-Aminoalkyl-β-carboline-3-carboxamides, a Novel Orally Active Class of Antimalarials

Therapeutic efficacy of antimalarial drugs targeting DosRS signaling in Mycobacterium abscessus

Active Pharmacovigilance for Primaquine Radical Cure of Plasmodium vivax Malaria in Odisha, India

Malaria in the time of COVID: Through the looking glass

IMI European Lead Factory - democratizing access to high-throughput screening

World Malaria Report 2021

Tafenoquine exposure assessment, safety, and relapse prevention efficacy in children with Plasmodium vivax malaria: open-label, single-arm, non-comparative, multicentre, pharmacokinetic bridging, phase II trial

Ex Vivo Plasmodium malariae Culture Method for Antimalarial Drugs Screen in the Field

Host-directed therapy, an untapped opportunity for antimalarial intervention

Eliminating malaria in southeast Asia requires more attention on adolescent girls

Increasing access to malaria interventions for adolescent girls is an important step toward malaria elimination

Probing the distinct chemosensitivity of Plasmodium vivax liver stage parasites and demonstration of 8-aminoquinoline radical cure activity in vitro

Best of British: How British-backed science can accelerate the end of malaria

New Scalable Synthetic Routes to ELQ-300, ELQ-316, and Other Antiparasitic Quinolones

Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates

MMV at a glance

Prioritization of Molecular Targets for Antimalarial Drug Discovery

Decreased Susceptibility to Dihydrofolate Reductase Inhibitors Associated With Genetic Polymorphisms in Ugandan Plasmodium falciparum Isolates

Unanticipated CNS Safety Signal in a Placebo-Controlled, Randomized Trial of Co-Administered Atovaquone-Proguanil and Amodiaquine.

Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials

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