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715 found

The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance.

Scientific article

Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439

Scientific article

The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.

Scientific article

Rapport de gestion 2020

MMV Annual Report

Annual Report 2020

MMV Annual Report

Seeking an optimal dosing regimen for OZ439/DSM265 combination therapy for treating uncomplicated falciparum malaria

Scientific article

Gender issues must not be an afterthought in global health research

Advocacy article

Pyronaridine-artesunate real-world safety, tolerability, and effectiveness in malaria patients in 5 African countries: A single-arm, open-label, cohort event monitoring study

Scientific article

Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors.

Scientific article

MalDA, Accelerating Malaria Drug Discovery

Scientific article

Perception of Malaria Chemoprevention Interventions in Infants and Children in Eight Sub-Saharan African Countries: An End User Perspective Study

Scientific article

Participatory research for the development of information, education and communication tools to promote intermittent preventive treatment of malaria in pregnancy in the Democratic Republic of the Congo, Nigeria and Mozambique.

Scientific article

Efficacy, Safety and Tolerability of Pyronaridine-artesunate in Asymptomatic Malaria-infected Individuals: a Randomized Controlled Trial.

Scientific article

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.

Scientific article

Empower local communities, avert future disease outbreaks

Advocacy article, External publication

Actives from MMV Open Access Boxes? A suggested way forward.

Scientific article

Zeroing in on malaria elimination: Final report of the E-2020 initiative

External publication

Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines.

Scientific article

Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2.

Scientific article

Humans’ oldest foe: fighting malaria in the face of resistance

External publication

Accelerating global health R&D: the role of product development partnerships

External publication

Parasite-Host Dynamics throughout Antimalarial Drug Development Stages Complicate the Translation of Parasite Clearance.

Scientific article

Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum

Scientific article

Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts

Scientific article

MAIP: a web service for predicting blood-stage malaria inhibitors.

Scientific article

Not only COVID-19: public-private partnerships delivering new drugs to fight diseases of poverty

Advocacy article

Hepatic safety of repeated treatment with pyronaridine-artesunate versus artemether-lumefantrine in patients with uncomplicated malaria: a secondary analysis of the WANECAM 1 data from Bobo-Dioulasso, Burkina Faso.

Scientific article

Keeping the Promise: Product Development Partnerships’ Role in the New Age of Health Research and Product Development

External publication

1-Methyl-1 H-pyrazole-5-carboxamide Derivatives Exhibit Unexpected Acute Mammalian Toxicity

Scientific article

Pregnancy registries: a step towards better antimalarials for women

Advocacy article

Retrospective Analysis Using Pharmacokinetic/Pharmacodynamic Modeling and Simulation Offers Improvements in Efficiency of the Design of Volunteer Infection Studies for Antimalarial Drug Development.

Scientific article

Effectiveness of seasonal malaria chemoprevention at scale in west and central Africa: an observational study

Access article / report

World Malaria Reports

World Malaria Report 2020

External publication

Q&A: Scaling up preventive malaria treatment in pregnancy by enhancing African manufacturing capacity

Advocacy article

Escaping from Flatland: Antimalarial Activity of sp³-Rich Bridged Pyrrolidine Derivatives.

Scientific article

The impact of delayed treatment of uncomplicated P. falciparum malaria on progression to severe malaria: A systematic review and a pooled multicentre individual-patient meta-analysis.

Scientific article

International Day of the Girl Child: Get up, speak out and save adolescent girls from malaria

Advocacy article

MiMBa: Combatting malaria in pregnant and breastfeeding women

External publication

Efficacy and Safety of Pyronaridine-Artesunate for the Treatment of Uncomplicated Plasmodium falciparum and Plasmodium vivax Malaria in Myanmar.

Scientific article

Lipid Compositions in Infant Formulas Affect the Solubilization of Antimalarial Drugs Artefenomel (OZ439) and Ferroquine during Digestion

Scientific article

MMV Rapport Annuel 2019

MMV Annual Report

MMV Annual Report 2019

MMV Annual Report

Plasmodium vivax liver stage assay platforms using Indian clinical isolates.

Scientific article

MMV at a glance

Discovery of Anti-Amoebic Inhibitors from Screening the MMV Pandemic Response Box on Balamuthia mandrillaris, Naegleria fowleri, and Acanthamoeba castellanii

Scientific article

Pharmacogenetic assessment of tafenoquine efficacy in patients with Plasmodium vivax malaria

Scientific article

First-in-human clinical trial to assess the safety, tolerability and pharmacokinetics of P218, a novel candidate for malaria chemoprotection.

Scientific article

OPT-SMC: Implementation research to optimize delivery and effectiveness of seasonal malaria chemoprevention

Access article / report, External publication

A screening of the MMV Pathogen Box® reveals new potential antifungal drugs against the etiologic agents of chromoblastomycosis.

Pathogen Box article, Scientific article

The malaria season is coming – we must continue to protect children at risk

External publication

Photo: Gerasimov174

Novel Endochin-Like Quinolones Exhibit Potent In Vitro Activity against Plasmodium knowlesi but Do Not Synergize with Proguanil.

Scientific article

Targeting Plasmepsins-An Achilles' Heel of the Malaria Parasite.

Scientific article

WHO's Q&A on malaria and the COVID-19 pandemic

External publication

Diversity, Inclusion and Equity at MMV: Principles, Policies and Practices

MiMBa: Malaria in Mothers and Babies

Advocacy article, MMV issues in focus

Neurological and psychiatric safety of tafenoquine in Plasmodium vivax relapse prevention: a review

Scientific article

Ensemble modeling highlights importance of understanding parasite-host behavior in preclinical antimalarial drug development.

Scientific article

Closing the gender gap in medical research

External publication

Factors affecting the electrocardiographic QT interval in malaria: A systematic review and meta-analysis of individual patient data

Scientific article

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