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Abena Poku-Awuku
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Maud Majeres Lugand
Maëlle Duffey
Mohammed Cherkaoui
Myriam El Gaaloul
Mélanie Rouillier
Nada Abla Geiser
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Nathalie Gobeau
Paul Willis
Pierre Hugo
Silvia Ferazzi
Stephan Duparc
Stephan Chalon
Stephen Brand
Sylvie Fonteilles-Drabek
Tim Wells
Wiweka Kaszubska
Zaira Rizopoulos

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Publications

IMI European Lead Factory - democratizing access to high-throughput screening

World Malaria Report 2021

Tafenoquine exposure assessment, safety, and relapse prevention efficacy in children with Plasmodium vivax malaria: open-label, single-arm, non-comparative, multicentre, pharmacokinetic bridging, phase II trial

Host-directed therapy, an untapped opportunity for antimalarial intervention

Eliminating malaria in southeast Asia requires more attention on adolescent girls

Increasing access to malaria interventions for adolescent girls is an important step toward malaria elimination

Probing the distinct chemosensitivity of Plasmodium vivax liver stage parasites and demonstration of 8-aminoquinoline radical cure activity in vitro

Best of British: How British-backed science can accelerate the end of malaria

New Scalable Synthetic Routes to ELQ-300, ELQ-316, and Other Antiparasitic Quinolones

Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates

MMV at a glance

Prioritization of Molecular Targets for Antimalarial Drug Discovery

Decreased Susceptibility to Dihydrofolate Reductase Inhibitors Associated With Genetic Polymorphisms in Ugandan Plasmodium falciparum Isolates

Unanticipated CNS Safety Signal in a Placebo-Controlled, Randomized Trial of Co-Administered Atovaquone-Proguanil and Amodiaquine.

Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials

Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity

Entamoeba Chitinase is Required for Mature Round Cyst Formation

Assessing risks of Plasmodium falciparum resistance to select next-generation antimalarials

Ex vivo susceptibility to new antimalarial agents differs among human-infecting Plasmodium species

The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance

Plasmodium malariae and Plasmodium falciparum comparative susceptibility to antimalarial drugs in Mali

Cross-resistance of the chloroquine-derivative AQ-13 with amodiaquine in Cambodian Plasmodium falciparum isolates

Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439

The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance

Annual Report 2020

Rapport de gestion 2020

Seeking an optimal dosing regimen for OZ439/DSM265 combination therapy for treating uncomplicated falciparum malaria

Gender issues must not be an afterthought in global health research

Pyronaridine-artesunate real-world safety, tolerability, and effectiveness in malaria patients in 5 African countries: A single-arm, open-label, cohort event monitoring study

Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors

A Molecular Signature for Il-10-Producing Th1 Cells in Protozoan Parasitic Diseases

MalDA, Accelerating Malaria Drug Discovery

Perception of Malaria Chemoprevention Interventions in Infants and Children in Eight Sub-Saharan African Countries: An End User Perspective Study

Participatory research for the development of information, education and communication tools to promote intermittent preventive treatment of malaria in pregnancy in the Democratic Republic of the Congo, Nigeria and Mozambique

A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria

Efficacy, Safety and Tolerability of Pyronaridine-artesunate in Asymptomatic Malaria-infected Individuals: a Randomized Controlled Trial

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series

Longitudinal study based on a safety registry for malaria patients treated with artenimol-piperaquine in six European countries

Empower local communities, avert future disease outbreaks

Actives from MMV Open Access Boxes? A suggested way forward

Zeroing in on malaria elimination: Final report of the E-2020 initiative

Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines

Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2

Accelerating global health R&D: the role of product development partnerships

Humans’ oldest foe: fighting malaria in the face of resistance

Parasite-Host Dynamics throughout Antimalarial Drug Development Stages Complicate the Translation of Parasite Clearance

Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum

Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts

MAIP: a web service for predicting blood-stage malaria inhibitors

Not only COVID-19: public-private partnerships delivering new drugs to fight diseases of poverty

Hepatic safety of repeated treatment with pyronaridine-artesunate versus artemether-lumefantrine in patients with uncomplicated malaria: a secondary analysis of the WANECAM 1 data from Bobo-Dioulasso, Burkina Faso

Keeping the Promise: Product Development Partnerships’ Role in the New Age of Health Research and Product Development

1-Methyl-1 H-pyrazole-5-carboxamide Derivatives Exhibit Unexpected Acute Mammalian Toxicity

Pregnancy registries: a step towards better antimalarials for women

Retrospective Analysis Using Pharmacokinetic/Pharmacodynamic Modeling and Simulation Offers Improvements in Efficiency of the Design of Volunteer Infection Studies for Antimalarial Drug Development

Effectiveness of seasonal malaria chemoprevention at scale in west and central Africa: an observational study

World Malaria Report 2020

World Malaria Reports

Q&A: Scaling up preventive malaria treatment in pregnancy by enhancing African manufacturing capacity

Escaping from Flatland: Antimalarial Activity of sp3-Rich Bridged Pyrrolidine Derivatives

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Escaping from Flatland: Antimalarial Activity of sp³-Rich Bridged Pyrrolidine Derivatives