Monoclonal Antibodies for Malaria
Malaria is a devastating disease. It was the cause of 627,000 deaths worldwide in 2020, and malaria-related mortality has increased by more than 10% over the past 3 years. Although there are highly effective treatments, the development of multidrug-resistant strains poses a great threat to the control and elimination of malaria. Moreover, prevention is a better strategy than treatment. Despite several approaches to prevent established infection, no single approach offers complete protection, so a multilayered approach is needed. One potential layer, the monoclonal antibody is the focus of a trial by Wu and colleagues1 and the editorial by Daily2 in this issue of the Journal. They describe protection conferred by a long-acting, next-generation monoclonal antibody against controlled human malaria infection in healthy persons.
To view the full article, please visit the New England Journal of Medicine website.
1. Wu RL, Idris AH, Berkowitz NM, et al. Low-dose subcutaneous or intravenous monoclonal antibody to prevent malaria. N Engl J Med 2022;387:397-407.
2. Daily JP. Monoclonal antibodies — a different approach to combat malaria. N Engl J Med 2022;387:460-461.