Stopping the relapse
Dr Alejandro Llanos, Universidad Peruana Cayetano Heredia, Lima, Peru
The dormant liverstage form of P. vivax, which can reactivate without warning leading to the feverish symptoms of malaria, remains a challenge to treat. Dr Alejandro Llanos talks about why there is a need for new medicines to treat relapsing malaria in Peru.
Treating children suffering from malaria
Dr Jane Achan, Makerere University, Kampala, Uganda
With the exception of Coartem® Dispersible, few antimalarial medicines have been specifically formulated for children. Dr Jane Achan explains the needs on the ground for doctors treating children suffering from malaria.
Developing medicines for children
Dr Isabelle Borghini-Fuhrer Director, Clinical Development, MMV
Few antimalarial medicines have been specifically formulated to provide children with age and weight-appropriate doses in a palatable form. Dr Isabelle Borghini-Fuhrer explains the challenges in the development of medicines for children and MMV’s strategy to overcome them.
Protecting pregnant women and their babies
Dr Elizabeth Juma, National Malaria Control Programme, Kenya
Pregnancy lowers a woman’s immune response to infections and so she is four-times more likely to get malaria and twice as likely to die from it than another adult. Dr Elizabeth Juma explains Kenya's approach to protecting pregnant women from malaria.
Preventing stock-outs: SMS for Life
Mr Winna Shango, Ministry of Health and Social Welfare, Tanzania
SMS for Life uses widely available SMS technology to record antimalarial stock levels at the point-of-care. Mr Winna Shango tells us how this programme is motivating health-care workers in Tanzania.
From procurement to patients
Mrs Esnet Mwape, Pharmaceutical Regulatory Authority, Zambia
ACTs are currently the best medicines available to treat uncomplicated malaria but unfortunately many patients lack access to them. Ms Esnet Mwape explains how the medicinal products coming into Zambia are now better regulated.
Bringing all the right ingredients together
In 2011 Eurartesim® was approved by the European Medicines Agency (EMA) – the first new European antimalarial medicine for over a decade. This is a huge achievement, and takes the medicine a step closer to the patients that so sorely need it.
The world’s first producer of WHO prequalified artesunate for injection for severe malaria
Guilin Pharmaceutical, China
Guilin Pharmaceutical has been producing intravenous (IV) artesunate for patients with severe malaria since 1987. But without WHO prequalification or stringent regulatory approval, it could not be purchased by international organizations or donor funds.
Analyzing the antimalarials market
Nettie Dzabala, College of Medicine, Malawi
The College of Medicine is an academic centre of excellence, responsive to the health needs of Malawi by training professionals, providing clinical services and medical research. MMV worked with the college to analyze the antimalarial medicines market in six districts.
OZ439: A winning network of partners
Prof. Jonathan Vennerstrom, Prof. Susan Charman & Dr Sergio Wittlin
The success of the OZ439 project can be attributed to the commitment, enthusiasm and range of scientific expertise of its partners from across the globe. Today, OZ439 is on track to potentially replace artemisinin and become a part of the much-needed one-dose cure for malaria.
Feeding the drug development pipeline through the discovery of novel chemistry
Dr Thierry Diagana, Novartis Institue for Tropical Diseases, Singapore
NITD is working in close collaboration with MMV to explore new drug discovery approaches for malaria. NITD609, if proven to be well tolerated, will be the first antimalarial not belonging to either the artemisinin or peroxide class to enter clinical efficacy studies in recent years.
Guiding the development of transmission-blocking medicines
Prof. Robert Sinden, Imperial College, London, UK
Current medicines mostly kill the malaria parasite at the blood stage, but to eradicate malaria, we need to stop the parasite being passed on to the next person via mosquitos. Imperial College London has been working with MMV to turn basic biology into knowledge to underpin the development of new antimalarials.
A weapon to counter resistance
Dr Jörg Möhrle, Head of Translational Medicine, MMV
OZ439 is a fully synthetic peroxide on track to provide not only a single-dose cure for malaria, but also a potential alternative to currently used artemisinin derivatives. Dr Jörg Möhrle explains this molecule.
A long-standing collaboration
Shin Poong Pharmaceutical, South Korea
MMV and Shin Poong have worked together since 1999 to develop Pyramax®. This new once daily, 3-day treatment for uncomplicated P. falciparum and blood stage P. vivax malaria in infants, children and adults is awaiting regulatory approval by the European Medicines Agency.
Treating patients with severe malaria
Dr Arjen Dondorp, Deputy Director and Head of Malaria Research,Mahidol–Oxford Tropical Medi-cine Research Unit, Bangkok, Thailand
MMV is using its R&D know-how, working with Guilin Pharmaceutical to achieve WHO prequalification for injectale artesunate, treatment for severe malaria. Dr Arjen Dondorp, speaks about treating patients with of severe malaria.
DHODH: Academic brain meets industrial muscle
Dr Meg Phillips, University of Texas Southwestern, USA
The enzyme DHODH is one the hottest malaria drug targets under investigation today. This project was awarded MMV’s 2010 Project of the Year in recognition of its impressive progress to rapidly bring these inhibitors towards clinical testing. Dr Meg Phillips speaks about the collaboration with MMV.
Overcoming the challenges of conducting clinical trials in India
Dr Neena Valecha, The National Institute of Malaria Research, India
NIMR is India’s premier malaria research institute, carrying out studies on drug resistance, and Phase II/ III trials of new drugs. Conducting clinical trials in India is a challenge but MMV and NIMR have had a successful partnership.
Delivering good, affordable drugs to those in need
Prof. Bruno Gryseels & Prof. Umberto D’Alessandro, ITM, Belgium
ITM provides postgraduate training for medical doctors and paramedics – a number of whom are headed for central Africa. Collaboration between MMV and ITM focuses on the development and trial of new antimalarials.