Malaria liver-stage biology

01 Jul 2017

Following an infective mosquito bite, sporozoites travel via the blood to the liver.

Here they develop into schizonts, which then burst and release merozoites into the blood, leading to the clinical symptoms of malaria. In some species of parasite, particularly P. vivax, some sporozoites become hypnozoites.

This form lies dormant in the liver and can reactivate leading to schizont formation and the ensuing symptoms of malaria in the absence of an infectious mosquito bite.