This infographic explains malaria transmission biology and the assays to identify compounds to block it. Read more below.
MMV’s strategy is to identify compounds able to kill the asexual blood stages and gametocytes, thus curing the patient and blocking transmission. To do so, we have a cascade of tests in place. Blood-stage active compounds are screened against a gametocyte assay, followed by a male and female gamete formation assay followed by the Standard Membrane Feeding Assay (SMFA).