Tropical Medicine and Infectious Disease Webinar | Malaria Chemoprevention Strategies

28 March 2022, 13:30 CET / 07:30 EDT / 19:30 CST

Chemoprevention strategies are expected to contribute significantly to malaria control and elimination if largely deployed in malaria endemic settings. Intervention such as intermittent preventive treatment in pregnant women (IPTp) and seasonal malaria chemoprevention (SMC) have proven to be highly effective, even though development of resistance to the current regimens (sulfadoxine-pyrimethamine and amodiaquine) warrants the implementation of alternative antimalarial drugs in the near future. Intermittent preventive treatment in infants (IPTi) has been shown to have a substantial impact on morbidity and malaria-related anemia, but its full impact is yet to be investigated in large-scale implementation studies. As transmission decreases in some settings, there is an age shifting of disease burden in older infants, and intermittent preventive treatment in schoolchildren (IPTc) is being explored in some countries. Mass drug administration (MDA) is another strategy, mainly used in elimination settings that has been shown to work in some settings, but not in others. Specific strategies are also needed for P.vivax, as the implementation of radical cure drug-based strategies is associated with potential lethal hemolysis in G6PD-deficient patients. To maximize the impact of all those interventions, new antimalarial drugs will be required, as the effectiveness of those currently used is either decreasing or may decrease in the near future. In the meantime, innovative strategies must be implemented to extend the useful therapeutic lifespan of the antimalarial drugs we currently have, and different drugs should be used for chemoprevention and case management to reduce drug pressure and minimize the chances of drug resistance development. In this webinar, we have invited three experts to discuss about the challenges in the implementation of chemoprevention strategies in malaria endemic countries.

André-Marie Tchouatieu

Perception of Malaria Chemoprevention Interventions in Infants and Children in Eight Sub-Saharan African Countries: An End User Perspective Study