ZY19489+ ferroquine

Zydus
Asexual blood stages
Uncomplicated malaria treatments and resistance management (TPP-1)

ZY19489+ ferroquine

Product development
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Patient exploratory
Product vision
  • Uncomplicated malaria treatment and resistance management
MOA
  • ZY19489 new class of inhibitors, no resistance detected in vitro, mechanism of action unknown
  • Ferroquine (FQ), a 4-aminoquinoline: inhibition of haem detoxification
Key features
  • ZY19489: No stable resistance detected in in vitro or clinical studies
  • FQ: long duration of plasma exposure, fully active against amodiaquine and piperaquine resistant strains
Challenges
  • ZY19489: Synthesis and cost of goods
Status
  • ZY19489 phase I Multiple Ascending Dose completed in 2022
  • FQ: Two phase II studies in combination with OZ439 were completed in 2020; discovered by CNRS Lille and transferred to Sanofi; rights transferred from Sanofi to MMV
Next milestone
  • Completion of combination toxicology study
  • Initiate phase IIb combination study
Previously
  • ZY19489 discovery partnership between MMV and AstraZeneca, Bangalore
  • ZY19489 name AZ13721412; full reference name is MMV674253