Sulfadoxine- pyrimethamine+ amodiaquine dispersible

Sulfadoxine- pyrimethamine+ amodiaquine dispersible

Access
-
Approved
SPAQ-CO™
Fosun Pharma
Paediatric formulation
Intermittent preventative treatment (TPP-1)
Therapeutic indication
  • Seasonal Malaria Chemoprevention (SMC) for children most at risk of severe malaria in areas with seasonal malaria transmission

Dosing
  • Once daily for 3 days (amodiaquine) and one day (sulfadoxine-pyrimethamine), administered in monthly cycles during peak malaria transmission season

Efficacy
  • 75% reduction in malaria episodes in pivotal trials

Key features
  • Recommended by WHO since 2012 for the prevention of malaria in children in areas of high seasonal malaria transmission

  • 3-year shelf life

Challenges
  • Drug distribution via door-to-door campaigns
Status
  • 882 million treatments distributed since launch in 2012
  • First taste-masked dispersible SPAQ formulation prequalified by WHO
Next milestone
  • Validation of dose and development of packaging or formulation  for children from 5-10 years
  • Seasonality stratification in all countries to define number of rounds of SMC ongoing
  • Adoption of a fifth monthly round of treatment in areas with longer seasonal transmission
  • Adoption in areas outside of the Sahel region
Project Director
  • Dr André-Marie Tchouatieu