Ganaplacide-lumefantrine

Novartis
Asexual blood stages
Transmission reduction
Chemoprevention
Uncomplicated malaria treatments and resistance management (TPP-1)

Ganaplacide-lumefantrine

Product development
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Patient exploratory
Product vision
  • Uncomplicated malaria treatment and resistance management
MOA
  • Recent ganaplacide data suggest effect on parasite internal protein secretory pathway. Target not yet fully determined. Decreased susceptibility to ganaplacide is associated with mutations in three P. falciparum genes, CARL (cyclic amine resistance locus), UDP-galactose and Acetyl-CoA transporters
  • Lumefantrine inhibits the parasite conversion of toxic heme to non-toxic hemozoin
Key features

Ganaplacide

  • Novel mechanism of action – activity against parasites that are resistant to current drugs

  • Rapid killing of parasites (parasite clearance time <48 hours)

  • Effective against P. falciparum and P. vivax species

  • Transmission-blocking activity in a Standard Membrane Feeding Assay

  • Potential for causal prophylaxis by blocking early liver stage of parasite

Lumefantrine

  • Used in combination with artemether since 1998 in over 1 billion patients

  • New lumefantrine formulation with improved release profile bioavailability
Status

  • Phase IIb combination studies completed

  • Phase IIb study in paediatric population (KALUMI) ongoing
Next milestone

  • Completion of Phase IIb KALUMI studies

  • Phase III study start
Previously
  • KAF156, GNF156. Novartis in discovery partnership with MMV, Wellcome Trust, and the Swiss Tropical and Public Health Institute