Atoguanil

Translational

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Human volunteers

Ipca

Chemoprevention

Intermittent preventative treatment (TPP-1)

Chemoprophylaxis (TPP-2)

Product vision	Intermittent preventive treatment and chemoprevention
MOA	Atocaquone and proguanil interfere with two pathways involved in the biosynthesis of pyrimidines required for nucleic acid replication. Atovaquone acts against P. falciparum via inhibition of mitochondrial electron transport
Key features	Liver-stage activity and prophylactic efficacy Lower doses of atovaquone required in the combination leading to lower cost of goods
Challenges	Obtaining comparable bioavailability to atovaquone-proguanil with half the atovaquone dose Obtaining cost of goods suitable for chemoprevention
Status	Relative bioavailability study between atoguanil and atovaquone-proguanil completed Programme terminated
Next milestone	N/A
Project Director	Dr Isabelle Borghini-Fuhrer