Malaria Libre data repository

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Aryl piperazine

MoA/MoR: Unknown (no cross resistance identified)
Key features: Physicochemical and DMPK properties can be modulated with structural modifications Fast rate of killing in vitro Probably new mode of action
Challenges: Most compounds associated with high CYP inhibition
Status: Validated hit
Next milestone: Identification of early lead
MMV024406 analogs data

MoA/MoR:Unknown (no cross resistance identified)

Key features:

Possibility to move away from hidden anilines and modulation of physicochemical properties with structural modifications
Fast rate of killing in vitro
Likely new mode of action

Challenges: Poor metabolic stability

Status: Validated hit

Next milestone: Identification of early lead