The ACT artesunate-mefloquine (ASMQ), developed by DNDi and Farmanguinhos and manufactured by Cipla via a technology transfer, was prequalified by WHO in 2012.
As one of five ACTs recommended by WHO for the treatment of uncomplicated P. falciparum malaria, ASMQ has an important role to play in the global effort to improve timely access to treatment. Currently, ASMQ is the recommended first- or second-line treatment in five countries in South America and four countries in Southeast Asia. Recently, ASMQ has been identified as the preferred alternative to dihydroartemisinin-piperaquine (DHA-PQP) in parts of Cambodia where rising levels of drug resistance have diminished the efficacy of DHA-PQP.
Through an agreement with DNDi in 2015, MMV agreed to take over access stewardship of ASMQ, supporting product adoption and use per its recommended label, and helping disseminate evidence-based information regarding product efficacy and safety for consideration by national treatment programmes in line with WHO’s guidance.
In July 2016, a new study by Sirima et al evaluating ASMQ’s safety and efficacy in young African children (6-59 months old) was published in The Lancet. The results showed that the safety and efficacy of ASMQ were comparable to those of dispersible artemether-lumefantrine. In addition, ASMQ was as well tolerated as the comparator drug, and rates of re-infection appeared lower in the ASMQ arm, probably due to the longer half-life of mefloquine compared to lumefantrine.