Sam Jones

Manager, PKPD Modelling
Research & Development

What I do at MMV:

I provide pharmacokinetic and pharmacodynamic modelling to help develop novel antimalarial compounds. The techniques used allow for analysis of clinical and non-clinical studies, as well as assessment and interpretation of pharmacokinetic effects that occur when administering compounds in combination. 

Why I work at MMV:

Malaria is a disease affecting primarily the world’s poorest populations, with most deaths occurring in young children. I believe that eradication of malaria is an achievable goal within our lifetime. I am motivated by the public health benefits that will accrue from successful strategies for the prevention and treatment of malaria. On a personal level, I am excited to be able to develop and utilize mathematical and computational modelling techniques to contribute to the evidence base that will support the battle against malaria. 

More about me:

I completed an MSc in Epidemiology at Imperial College London in 2014 after becoming interested in mathematical modelling of infectious disease during my BSc Biomedical Science degree at the University of Warwick (2010-2013). I then completed my PhD at the Liverpool School of Tropical Medicine on modelling approaches for improving analysis of antimalarial clinical trials. 

Following my thesis, I worked as a research assistant at the Liverpool School of Tropical Medicine, carrying out work on novel genetic markers with which to interpret treatment failures in antimalarial efficacy trials as well as investigating the consequences of different insecticide deployment strategies on the lifespan of insecticide treated bed-nets.

A recurring theme in my research is the threat posed by resistance – either parasite resistance to antimalarial drugs or mosquito resistance to insecticides. I am particularly motivated by promoting good stewardship of existing and novel compounds to mitigate or prevent the emergence of drug resistance. 

Ask me about:

Mechanistic-based pharmacokinetic / pharmacodynamic models, antimalarial clinical trials, R programming language, malaria epidemiology. Outside of work: All things mountain biking, bouldering and skiing, craft beer and board games.